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KMID : 1003219970030010066
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Journal of Korean Oriental Chronic Disease
1997 Volume.3 No. 1 p.66 ~ p.77
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Inhibition of Immunoglobulin E-Mediated Aanaphylaxis by Modified Hwanglyunhaedoktang
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尹星燦/Yoon, Sung Chan
宋峰根/金炯均/李彦政/Song, Bong Keun/Kim, Hyeong Kyun/Lee, Eon Jeong
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Abstract
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Modified Hwanglyunhaedoktang has been used against allergic disease for generations, and still occupies an important place in Oriental medicine. In this study, the author investigated the effect of Modified Hwanglyunhaedoktang on immunoglobulin E-mediated anaphylaxis activated by anti-dinitrophenyl immunoglobulin E antibody. Modified Hwanglyunhaedoktang potently inhibited passive cutaneous anaphylaxis when intradermally, intraperitoneally, and orallly administered. On the other hand, it showed poor inhibitory activity when intravenously administered. Moreover, Modified Hwanglyunhaedoktang inhibited anaphylactic histamine release from peritoneal mast cells activated by anti-dinitrophenyl immunoglobulin E antibody. These results indicate that Modified Hwanglyunhaedoktang inhibits the passive cutaneous anaphylaxis by inhibition of histamine release from mast cells in vivo and in vitro and also suggest that the differential activity following prescription routes may be caused by the difference of bioavailability.
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KEYWORD
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